Prioritize PD to extend residual kidney function

Residual Kidney Function (RKF) is associated with improved survival

The majority of patients starting dialysis have residual kidney function (RKF).

Graphic showing reduced risk

RKF is associated with better patient survival

Prospective randomized trials of dialysis adequacy and observational studies have confirmed an association between the presence of RKF and improved patient survival during chronic PD therapy

  • Each 250 mL increase in daily urine volume is associated with a 36% lower relative risk of death1
  • A residual GFR increase of 1 mL/min/1.73 m2 has been shown to give a 12% reduction in relative risk of death2
Graph showing higher residual GFR

PD allows a better preservation of RKF than Hemodialysis (HD), favoring starting on PD first

Evidence shows that patients treated with PD compared with those treated with HD have:

  • A slower rate of decline of residual glomerular filtration rate (rGFR) and creatinine clearance3
  • A longer time to loss of RKF1-3