Bridge to Transplant

PD is the ideal bridge to kidney transplant associated with favorable post-transplant outcomes1

  • Pre-transplant PD is associated with lower 5-year mortality after transplant than HD1
  • Pre-transplant PD was associated with lower risk of delayed graft function* Compared with HD1 (*unadjusted)

The 16 studies included in this meta-analysis showed favorable post-transplant outcomes with PD

Chart showing significant findings from a meta-analysis
Significant heterogeneity was observed for all outcomes: 
12  = 72.7%, 12  = 59.9%, and 12  = 66.8%, respectively. Adapted from Joachim E, et al. Perit Dial Int. 2017;37(3):259-265.

Six of the 16 studies demonstrated improvement of 5-year mortality in PD patients as compared to HD patients1

Charts showing five-year post-transplant mortality and graft survival
Adapted from Joachim E, et al. Perit Dial Int. 2017;37(3):259-265.

This meta-analysis suggests that PD may be the preferred dialysis modality for patients who expect to receive a renal transplant1


Meta-analysis methodology1

  • Two independent authors searched English-language literature from January 1, 1980, through August 31, 2014, national conference proceedings, and reference lists
  • The authors used combinations of terms related to dialysis (hemodialysis, peritoneal dialysis, or renal replacement therapy), kidney transplant, and outcomes
  • Studies were included if they measured any of the 3 post-transplant study outcomes in both pre-transplant HD and PD